AHL-Lactonase Producing Psychrobacter sp. From Palk Bay Sediment Mitigates Quorum Sensing-Mediated Virulence Production in Gram Negative Bacterial Pathogens
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چکیده
منابع مشابه
Attenuation of Quorum Sensing Regulated Virulence of Pectobacterium carotovorum subsp. carotovorum through an AHL Lactonase Produced by Lysinibacillus sp. Gs50
Quorum sensing (QS) is a mechanism in which Gram negative bacterial pathogens sense their population density through acyl homoserine lactones (AHLs) and regulate the expression of virulence factors. Enzymatic degradation of AHLs by lactonases, known as quorum quenching (QQ), is thus a potential strategy for attenuating QS regulated bacterial infections. We characterised the QQ activity of soil ...
متن کاملQuorum sensing mediated virulence inhibition of an opportunistic human pathogen Serratia marcescens from unexplored marine sediment of Palk Bay through function driven metagenomic approach
Indiscriminate use of antibiotics in treatment strategies of infections caused by opportunistic pathogen, Serratia marcescens has made the specimen multidrug resistant (MDR). The present study is focused to identify novel metaclones that selectively target quorum sensing mediated virulence factors of S. marcescens through culture independent approach. Metagenomic DNA library was constructed for...
متن کاملQuorum Sensing in Microbial Virulence
Cell-to cell communication occurs via a signaling pathway referred to as quorum sensing. There are four main types of these systems according to the chemical nature of signal molecules used by microorganisms to elicit expression of target genes in response to environmental stimuli or need of microbial communities. Type I system acts by using acyl homoserine lactones as signals to trigger the ex...
متن کاملDevelopment of Quorum-Based Anti-Virulence Therapeutics Targeting Gram-Negative Bacterial Pathogens
Quorum sensing is a cell density-dependent signaling phenomenon used by bacteria for coordination of population-wide phenotypes, such as expression of virulence genes, antibiotic resistance and biofilm formation. Lately, disruption of bacterial communication has emerged as an anti-virulence strategy with enormous therapeutic potential given the increasing incidences of drug resistance in pathog...
متن کاملQuorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways.
Numerous species of bacteria employ a mechanism of intercellular communication known as quorum sensing. This signaling process allows the cells comprising a bacterial colony to coordinate their gene expression in a cell-density dependent manner.1-3 Quorum sensing is mediated by small diffusible molecules termed autoinducers that are synthesized intracellularly (throughout the growth of the bact...
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ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2021
ISSN: 1664-302X
DOI: 10.3389/fmicb.2021.634593